Pregnancy and Estrogen Receptor Expression in a Large Congenital Nevus
نویسندگان
چکیده
Observations: A young woman was observed to have clinical lightening of her garment nevus and satellite nevi during 2 sequential pregnancies. Postpartum, the patient experienced darkening and repigmentation in her large garment nevus, with continued lightening of nearby satellite lesions. In addition to photographic documentation of these changes, biopsy samples taken during pregnant and nonpregnant periods underwent immunohistochemical evaluation for estrogen receptor (ER ), the predominant estrogen receptor in nevi and melanomas. Biopsy samples collected during pregnancy showed a decrease in nuclear staining for ER compared with samples collected after pregnancy. These changes in ER expression were not associated with histologic atypia during pregnancy or after delivery.
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